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Articles (41)
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Differential effect of drug interference in immunogenicity assays

Margreet H. Hart, Henk de Vrieze, Diana Wouters, Gerrit-Jan Wolbink, Joep Killestein, Els R. de Groot, Lucien A. Aarden, Theo Rispens

Journal:

Journal of Immunological Methods

Année:

2011

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2011

Disease models for immune and neurological disorders in non-human primates

Margreet Jonker, Michel Vierboom, Bert ‘t Hart

Journal:

Drug Discovery Today: Disease Models

Année:

2008

Langue:

english

Fichier:

PDF, 72 KB

english, 2008

Drug interference in immunogenicity assays depends on valency

Rispens, Theo, Hart, Margreet H., Ooijevaar-de Heer, Pleuni, van Leeuwen, Astrid, Vennegoor, Anke, Killestein, Joep, Wolbink, Gerrit-Jan, van der Kleij, Desiree

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Année:

2013

Langue:

english

Fichier:

PDF, 1.57 MB

english, 2013

Epstein-Barr virus-dependent lymphoproliferative disease: critical role of IL-6

Sandrine Mauray, Marie-Thérèse Fuzzati-Armentero, Philippe Trouillet, Marlies Rüegg, Grazia Nicoloso, Margreet Hart, Lucien Aarden, Marc Schapira, Michel A. Duchosal

Journal:

European Journal of Immunology

Année:

2000

Langue:

english

Fichier:

PDF, 233 KB

english, 2000

Asymptomatic synovitis precedes clinically manifest arthritis

Maarten C. Kraan, Hans Versendaal, Margreet Jonker, Barry Bresnihan, Wendy J. Post, Bert A. 't Hart, Ferdinand C. Breedveld, Paul P. Tak

Journal:

Arthritis & Rheumatism

Année:

1998

Langue:

english

Fichier:

PDF, 4.36 MB

english, 1998

Collagen-induced arthritis in an outbred group of rhesus monkeys comprising responder and nonresponder animals. Relationship between the course of arthritis and collagen-specific immunity

Nicolaas P. M. Bakker, Monique G. M. van Erck, Caroline A. D. Botman, Margreet Jonker, Bert A. 'T Hart

Journal:

Arthritis & Rheumatism

Année:

1991

Langue:

english

Fichier:

PDF, 784 KB

english, 1991

Resistance to collagen-induced arthritis in rats and rhesus monkeys after immunization with attenuated type II collagen

Bert A. 't Hart, Nicolaas P. M. Bakker, Margreet Jonker, Ronald E. Bontrop

Journal:

European Journal of Immunology

Année:

1993

Langue:

english

Fichier:

PDF, 686 KB

english, 1993

Non-human primate models of multiple sclerosis

Herbert P. M. Brok, Jan Bauer, Margreet Jonker, Erwin Blezer, Sandra Amor, Ronald E. Bontrop, Jon D. Laman, Bert A. ‘t Hart

Journal:

Immunological Reviews

Année:

2001

Langue:

english

Fichier:

PDF, 545 KB

english, 2001

Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis

Hanneke JM Kerkhof, Ingrid Meulenbelt, Andrew Carr, Antonio Gonzalez, Deborah Hart, Albert Hofman, Margreet Kloppenburg, Nancy E Lane, John Loughlin, Michael C Nevitt, Huibert AP Pols, Fernando Rivade

Journal:

BMC Medical Genetics

Année:

2010

Langue:

english

Fichier:

PDF, 353 KB

english, 2010

Morphological changes in diabetic kidney are associated with increasedO-GlcNAcylation of cytoskeletal proteins including α-actinin 4

Yoshihiro Akimoto, Yuri Miura, Tosifusa Toda, Margreet A Wolfert, Lance Wells, Geert-Jan Boons, Gerald W Hart, Tamao Endo, Hayato Kawakami

Journal:

Clinical Proteomics

Année:

2011

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2011

Monotherapy with the vitamin D3 analogue MC1288 does not result in prolonged kidney allograft survival in rhesus monkeys

Michel Vierboom, C. Johnsson, Bert ‘t Hart, Margreet Jonker

Journal:

Transplant International

Année:

2006

Langue:

english

Fichier:

PDF, 188 KB

english, 2006

Preclinical models of arthritic disease in non-human primates

Michel P.M. Vierboom, Margreet Jonker, Paul P. Tak, Bert A. ’t Hart

Journal:

Drug Discovery Today

Année:

2007

Langue:

english

Fichier:

PDF, 643 KB

english, 2007

Complexes between C1q and C3 or C4: Novel and specific markers for classical complement pathway activation

Diana Wouters, Hans D. Wiessenberg, Margreet Hart, Peter Bruins, Alexandre Voskuyl, Mohamed R. Daha, C. Erik Hack

Journal:

Journal of Immunological Methods

Année:

2005

Langue:

english

Fichier:

PDF, 274 KB

english, 2005

A novel method for the detection of antibodies to adalimumab in the presence of drug reveals “hidden” immunogenicity in rheumatoid arthritis patients

Pauline A. van Schouwenburg, Geertje M. Bartelds, Margreet H. Hart, Lucien Aarden, Gerrit Jan Wolbink, Diana Wouters

Journal:

Journal of Immunological Methods

Année:

2010

Langue:

english

Fichier:

PDF, 314 KB

english, 2010

Evaluating the validity of animal models for research into therapies for immune-based disorders

Bert A 't Hart, Sandra Amor, Margreet Jonker

Journal:

Drug Discovery Today

Année:

2004

Langue:

english

Fichier:

PDF, 257 KB

english, 2004

Treatment with Anti-MHC-Class-II Antibody Postpones Kidney Allograft Rejection in Primates but Increases the Risk of CMV Activation

Margreet Jonker, Jan Ringers, Eva-Maria Kuhn, Bert't Hart, Roland Foulkes

Journal:

American Journal of Transplantation

Année:

2004

Langue:

english

Fichier:

PDF, 87 KB

english, 2004

Soluble Human Interleukin-6 Receptor : Expression in Insect Cells, Purification and Characterization

Oliver Weiergräber, Ulrike Hemmann, Andrea Küster, Gerhard Müller-Newen, Johannes Schneider, Stefan Rose-John, Peter Kurschat, Just P. J. Brakenhoff, Margreet H. L. Hart, Silvia Stabel, Peter C. Heinr

Journal:

FEBS Journal

Année:

1995

Langue:

english

Fichier:

PDF, 970 KB

english, 1995

Purification and Characterization of the Soluble Interleukin-6 Receptor from Human Plasma and Identification of An Isoform Generated through Alternative Splicing

Gerhard Müller-newen, Christian Köhne, Radovan Keul, Ulrike Hemmann, Werner Müller-esterl, John Wijdenes, Just P. J. Brakenhoff, Margreet H. L. Hart, Peter C. Heinrich

Journal:

FEBS Journal

Année:

1996

Langue:

english

Fichier:

PDF, 803 KB

english, 1996

Peritoneal Interleukin-8 in Acute Appendicitis

Anneke M. Zeillemaker, Arthur A.G.M.Hoynck van Papendrecht, Margreet H.L. Hart, Dirk Roos, Henri A. Verbrugh, Piet Leguit

Journal:

Journal of Surgical Research

Année:

1996

Langue:

english

Fichier:

PDF, 85 KB

english, 1996

Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop

Nannette Brouwer, Koert M. Dolman, Rob van Zwieten, Ed Nieuwenhuys, Margreet Hart, Lucien A. Aarden, Dirk Roos, Taco W. Kuijpers

Journal:

Molecular Immunology

Année:

2006

Langue:

english

Fichier:

PDF, 464 KB

english, 2006

Correlation between genetic profile, serum levels and functionality of the polymorphic complement protein C4

Diana Wouters, Anneke van der Horst, Margreet Hart, Irma Rensink, Martin de Boer, Dennis Schooneman, Pauline van Schouwenburg, Judy Geissler, Dirk Roos, Lucien Aarden, Dörte Hamann

Journal:

Molecular Immunology

Année:

2007

Langue:

english

Fichier:

PDF, 51 KB

english, 2007

Phase II study on mannan-binding lectin (MBL) substitution in MBL-deficient children with chemotherapy-induced neutropenia

Nannette Brouwer, Florine Frakking, Michel van Houdt, Margreet Hart, Inga Laursen, Gunnar Houen, Ilona Kleine Budde, Paul Strengers, Koert Dolman, Marianne van de Wetering, Huib Caron, Taco Kuijpers

Journal:

Molecular Immunology

Année:

2007

Langue:

english

Fichier:

PDF, 57 KB

english, 2007

Towards a European nonhuman primate immune-tolerance network

Bert A ‘t Hart, Margreet Jonker

Journal:

Trends in Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 209 KB

english, 2002

Comparative analysis of inflammatory infiltrates in collagen-induced arthritis, kidney graft rejection and delayed-type hypersensitivity in non-human primates

Margreet Jonker, Jacqueline Wubben, Krista Haanstra, Michel Vierboom, Bert ‘t Hart

Journal:

Inflammation Research

Année:

2013

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2013

An ear swelling reaction for in vivo monitoring of inflammatory T cell activity in collagen-arthritic rats

Bert A. 't Hart, Elizabeth Kraakman, Margreet Jonker

Journal:

Journal of Immunological Methods

Année:

1994

Langue:

english

Fichier:

PDF, 461 KB

english, 1994

IgG4 Production Against Adalimumab During Long Term Treatment of RA Patients

Schouwenburg, Pauline A., Krieckaert, Charlotte L., Nurmohamed, Michael, Hart, Margreet, Rispens, Theo, Aarden, Lucien, Wouters, Diana, Wolbink, Gerrit Jan

Journal:

Journal of Clinical Immunology

Année:

2012

Langue:

english

Fichier:

PDF, 305 KB

english, 2012

Autoimmunity in non-human primates: the role of major histocompatibility complex and T cells, and implications for therapy

Jonker, Margreet, Bakker, Koos, Slierendregt, Bas, Hart, Bert 't, Bontrop, Ronald

Journal:

Human Immunology

Année:

1991

Langue:

english

Fichier:

PDF, 529 KB

english, 1991

Variable Mannose-Binding Lectin Expression during Postoperative Acute-Phase Response

Till, J. W. Olivier Van, Boermeester, Marja A., Modderman, Piet W., Sandick, Johanna W. Van, Hart, Margreet H.L., Gisbertz, Suzanne S., Lanschot, J. Jan B. Van, Aarden, Lucien A.

Journal:

Surgical Infections

Année:

2006

Langue:

english

Fichier:

PDF, 248 KB

english, 2006

Lipid-Mediated Enhancement of Transfection by a Nonviral Integrin-Targeting Vector

Hart, Stephen L., Arancibia-Cárcamo, Carolina V., Wolfert, Margreet A., Mailhos, Carolina, O'reilly, Nicola J., Ali, Robin R., Coutelle, Charles, George, Andrew J. T., Harbottle, Richard P., Knight, A

Journal:

Human Gene Therapy

Année:

1998

Langue:

english

Fichier:

PDF, 10.46 MB

english, 1998

Characterization of the natural immune response of rhesus monkey CD4+ve T cells to the bacterial antigen streptolysin O (SLO)

Kraakman, Elizabeth M., Bontrop, Ronald E., Groenesteln, Reno, Jonker, Margreet, Haaijman, Joost J., Hart, Bert A. ‘t

Journal:

Journal of Medical Primatology

Année:

1995

Langue:

english

Fichier:

PDF, 674 KB

english, 1995

Interleukin-8 Production by Human Peritoneal Mesothelial Cells in Response to Tumor Necrosis Factor-α, Interleukin-1, and Medium Conditioned by Macrophages Cocultured with Staphylococcus epidermidis

Michiel G. H. Betjes, Cornelis W. Tuk, Dirk G. Struijk, Raymond T. Krediet, Lambertus Arisz, Margreet Hart and Rob H. J. Beelen

Journal:

The Journal of Infectious Diseases

Année:

1993

Langue:

english

Fichier:

PDF, 1.41 MB

english, 1993

Endotoxin and Tumor Necrosis Factor-α-Induced Interleukin-8 Release in Humans

Sander J. H. van Deventer, Margreet Hart, Tom van der Poll, C. Erik Hack and Lucien A. Aarden

Journal:

The Journal of Infectious Diseases

Année:

1993

Langue:

english

Fichier:

PDF, 761 KB

english, 1993

TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2

Keizer, Mischa P., Pouw, Richard B., Kamp, Angela M., Patiwael, Sanne, Marsman, Gerben, Hart, Margreet H., Zeerleder, Sacha, Kuijpers, Taco W., Wouters, Diana

Journal:

European Journal of Immunology

Année:

2015

Langue:

english

Fichier:

PDF, 237 KB

english, 2015

The minipig as an alternative non-rodent model for immunogenicity testing using the TNFα blockers adalimumab and infliximab

van Mierlo, Geertje J. D., Cnubben, Nicole H. P., Wouters, Diana, Wolbink, Gerrit Jan, Hart, Margreet H. L., Rispens, Theo, Ganderup, Niels-Christian, Kuper, C. Frieke, Aarden, Lucien, Penninks, André

Journal:

Journal of Immunotoxicology

Année:

2014

Langue:

english

Fichier:

PDF, 341 KB

english, 2014

Lymphoid-Like Structures with Distinct B Cell Areas in Kidney Allografts are not Predictive for Graft Rejection. A Non-human Primate Study

Jonker, Margreet, Wubben, Jacqueline A. M., ‘t Hart, Bert A., Haanstra, Krista G.

Journal:

Inflammation

Année:

2015

Langue:

english

Fichier:

PDF, 1.10 MB

english, 2015

Characterization of Naturally Occurring CD4+CD25+ Regulatory T Cells in Rhesus Monkeys

Haanstra, Krista G., van der Maas, Martin J., ’t Hart, Bert A., Jonker, Margreet

Journal:

Transplantation Journal

Année:

2008

Langue:

english

Fichier:

PDF, 643 KB

english, 2008

No Synergy between ATG Induction and Costimulation Blockade Induced Kidney Allograft Survival in Rhesus Monkeys

Haanstra, Krista G., Sick, Ella A., Ringers, Jan, Wubben, Jacqueline A. M., Kuhn, Eva-Maria, ??t Hart, Bert A., Boon, Louis, Jonker, Margreet

Journal:

Transplantation Journal

Année:

2006

Langue:

english

Fichier:

PDF, 1.11 MB

english, 2006

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, M

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 2.97 MB

english, 2017

An Evaluation of 20 Years of EU Framework Programme-Funded Immune-Mediated Inflammatory Translational Research in Non-Human Primates

Haanstra, Krista G., Jonker, Margreet, ‘t Hart, Bert A.

Journal:

Frontiers in Immunology

Année:

2016

Langue:

english

Fichier:

PDF, 241 KB

english, 2016

Dynamics of circulating TNF during adalimumab treatment using a drug-tolerant TNF assay

Berkhout, Lea C., l’Ami, Merel J., Ruwaard, Jill, Hart, Margreet H., Heer, Pleuni Ooijevaar-de, Bloem, Karien, Nurmohamed, Michael T., van Vollenhoven, Ronald F., Boers, Maarten, Alvarez, Daniel F., S

Journal:

Science Translational Medicine

Année:

2019

Fichier:

PDF, 553 KB

2019

Clinical impact of antibodies against ustekinumab in psoriasis: an observational, cross-sectional, multicenter study

Loeff, Floris C., Tsakok, Teresa, Dijk, Lisanne, Hart, Margreet H., Duckworth, Michael, Baudry, David, Russell, Alice, Dand, Nick, van Leeuwen, Astrid, Griffiths, Christopher E.M., Reynolds, Nick J.,

Journal:

The Journal of Investigative Dermatology

Année:

2020

Fichier:

PDF, 834 KB

2020